YIR010W
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| Systematic name | YIR010W |
| Gene name | DSN1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:375431..377161 |
| Primary SGDID | S000001449 |
Description of YIR010W: Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation[1][2]
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Community Commentary
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Interactions
Genetic
YIR010W is a suppressor of MTW1
Strain Background: W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
DSN1 is a high copy suppressor of the mtw1-1 mutant. [3] [4]
Physical
Physical interaction with NSL1
Nsl1p co-immunoprecipitates Dsn1p. [3] [4]
Physical interaction with NNF1
Nnf1p co-immunoprecipitates Dsn1p. [3] [4]
Physical interaction with MTW1
Mtw1p co-immunoprecipitates Dsn1p. [3] [4]
Physical interaction with CSE4
Cse4p co-immunopreciptates with Dsn1p. [3] [4]
Physical interaction with MIF2
Mif2p co-immunoprecipitates Dsn1p. [3] [4]
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References
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- ↑ De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 SGD PMID 14633972
- ↑ Euskirchen GM (2002) Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell 1(2):229-40 SGD PMID 12455957
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 submitted by Benjamin Pinsky on 2004-03-04
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