YDR143C
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Systematic name | YDR143C |
Gene name | SAN1 |
Aliases | |
Feature type | ORF, Verified |
Coordinates | Chr IV:743874..742042 |
Primary SGDID | S000002550 |
Description of YDR143C: Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; contains intrinsically disordered regions that contribute to substrate recognition[1][2][3]
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Protein Details
Protein Function/Process
Nuclear-localized ubiquitin-protein ligase involved in the proteasome-dependent quality control degradation of aberrant nuclear proteins, including sir4-9, cdc68-1, sir3-8, and cdc13-1. [2] [4]
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References
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- ↑ Dasgupta A, et al. (2004) Sir Antagonist 1 (San1) is a ubiquitin ligase. J Biol Chem 279(26):26830-8 SGD PMID 15078868
- ↑ 2.0 2.1 Gardner RG, et al. (2005) Degradation-mediated protein quality control in the nucleus. Cell 120(6):803-15 SGD PMID 15797381
- ↑ Rosenbaum JC, et al. (2011) Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol Cell 41(1):93-106 SGD PMID 21211726
- ↑ submitted by Richard G. Gardner on 2005-11-09
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