YJL210W
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| Systematic name | YJL210W |
| Gene name | PEX2 |
| Aliases | CRT1, PAS5 |
| Feature type | ORF, Verified |
| Coordinates | Chr X:36919..37734 |
| Primary SGDID | S000003746 |
Description of YJL210W: RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import[1][2][3]
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Protein Details
Other Protein Details
Other Topic: Homology
Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [4] [5]
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References
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- ↑ Gould SJ and Valle D (2000) Peroxisome biogenesis disorders: genetics and cell biology. Trends Genet 16(8):340-5 SGD PMID 10904262
- ↑ Hazra PP, et al. (2002) Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Traffic 3(8):560-74 SGD PMID 12121419
- ↑ Platta HW, et al. (2009) Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol 29(20):5505-16 SGD PMID 19687296
- ↑ Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
- ↑ submitted by Toni Gabaldon on 2006-04-12
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