YGR140W
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| Systematic name | YGR140W | |
| Gene name | CBF2 | |
| Aliases | CBF3A, CEP2, CSL5, CTF14, NDC10 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr VII:767434..770304 | |
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Description of YGR140W: Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo[1][2][3]
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Interactions
Genetic
Strain Background: A364A/S288C
Genetic interaction with MIF2
Phenotype(s): Synthetic Lethal with MIF2
at the time showed that MIF2 genetically interacts with an "established" centromere protein gene [4] [5]
References
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- ↑ Espelin CW, et al. (2003) Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell 14(11):4557-68 SGD PMID 13679521
- ↑ Yoon HJ and Carbon J (1995) Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme. Mol Cell Biol 15(9):4835-42 SGD PMID 7651401
- ↑ Lechner J and Carbon J (1991) A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell 64(4):717-25 SGD PMID 1997204
- ↑ Meluh PB and Koshland D (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell 6(7):793-807 SGD PMID 7579695
- ↑ submitted by Pamela B. Meluh on 2003-03-17
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