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Systematic name YGR140W
Gene name CBF2
Aliases CBF3A, CEP2, CSL5, CTF14, NDC10
Feature type ORF, Verified
Coordinates Chr VII:767429..770299
Primary SGDID S000003372

Description of YGR140W: Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo[1][2][3]


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Strain Background: A364A/S288C
Genetic interaction with MIF2
Phenotype(s): Synthetic Lethal with MIF2

at the time showed that MIF2 genetically interacts with an "established" centromere protein gene [4] [5]



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  1. Espelin CW, et al. (2003) Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell 14(11):4557-68 SGD PMID 13679521
  2. Lechner J and Carbon J (1991) A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell 64(4):717-25 SGD PMID 1997204
  3. Yoon HJ and Carbon J (1995) Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme. Mol Cell Biol 15(9):4835-42 SGD PMID 7651401
  4. Meluh PB and Koshland D (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell 6(7):793-807 SGD PMID 7579695
  5. submitted by Pamela B. Meluh on 2003-03-17

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