YDR227W
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| Systematic name | YDR227W | |
| Gene name | SIR4 | |
| Aliases | ASD1, STE9, UTH2 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr IV:917567..921643 | |
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Description of YDR227W: Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan[1][2][3]
Contents
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Interactions
Two Hybrid
Two Hybrid interaction with UBP10
The N-terminal 250 aa of Ubp10p interacts with the C-terminus of Sir4p (residues 839-1358). [4] [5]
Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [6]
References
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- ↑ 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Moazed D, et al. (1997) Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A 94(6):2186-91 SGD PMID 9122169
- ↑ Kennedy BK, et al. (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80(3):485-96 SGD PMID 7859289
- ↑ Kahana A and Gottschling DE (1999) DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6608-20 SGD PMID 10490600
- ↑ submitted by Daniel E. Gottschling on 2003-03-17
- ↑ submitted by Jeff Ubersax on 2004-01-21
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