From SGD-Wiki
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YDR227W
Gene name SIR4
Aliases ASD1, STE9, UTH2
Feature type ORF, Verified
Coordinates Chr IV:917571..921647
Primary SGDID S000002635

Description of YDR227W: Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan[1][2][3]


Community Commentary

About Community Commentary. Please share your knowledge!


Two Hybrid

Two Hybrid interaction with UBP10
The N-terminal 250 aa of Ubp10p interacts with the C-terminus of Sir4p (residues 839-1358). [4] [5]

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [6]



See Help:References on how to add references

  1. Kennedy BK, et al. (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80(3):485-96 SGD PMID 7859289
  2. Moazed D, et al. (1997) Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A 94(6):2186-91 SGD PMID 9122169
  3. 3.0 3.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  4. Kahana A and Gottschling DE (1999) DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6608-20 SGD PMID 10490600
  5. submitted by Daniel E. Gottschling on 2003-03-17
  6. submitted by Jeff Ubersax on 2004-01-21

See Help:Categories on how to add the wiki page for this gene to a Category </protect>