YLR240W
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| Systematic name | YLR240W |
| Gene name | VPS34 |
| Aliases | END12, PEP15, STT8, VPL7, VPS7, VPT29 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:617535..620162 |
| Primary SGDID | S000004230 |
Description of YLR240W: Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p[1][2][3][4]
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References
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- ↑ Herman PK and Emr SD (1990) Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol Cell Biol 10(12):6742-54 SGD PMID 2247081
- ↑ Stack JH, et al. (1993) A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J 12(5):2195-204 SGD PMID 8387919
- ↑ Burda P, et al. (2002) Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J Cell Sci 115(Pt 20):3889-900 SGD PMID 12244127
- ↑ Slessareva JE, et al. (2006) Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126(1):191-203 SGD PMID 16839886
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