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Systematic name YLR240W
Gene name VPS34
Aliases END12, PEP15, STT8, VPL7, VPS7, VPT29
Feature type ORF, Verified
Coordinates Chr XII:617533..620160
Primary SGDID S000004230

Description of YLR240W: Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p[1][2][3][4]


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  1. Burda P, et al. (2002) Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J Cell Sci 115(Pt 20):3889-900 SGD PMID 12244127
  2. Herman PK and Emr SD (1990) Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol Cell Biol 10(12):6742-54 SGD PMID 2247081
  3. Slessareva JE, et al. (2006) Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126(1):191-203 SGD PMID 16839886
  4. Stack JH, et al. (1993) A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J 12(5):2195-204 SGD PMID 8387919

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