YGR023W

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Systematic name YGR023W
Gene name MTL1
Aliases
Feature type ORF, Verified
Coordinates Chr VII:529268..530923


Description of YGR023W: Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations[1][2][3][4]




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References

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  1. Vilella F, et al. (2005) Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J Biol Chem 280(10):9149-59 SGD PMID 15637049
  2. de Bettignies G, et al. (2001) Overactivation of the protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae. Genetics 159(4):1435-48 SGD PMID 11779787
  3. Ketela T, et al. (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40 SGD PMID 10348843
  4. Rajavel M, et al. (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol 19(6):3969-76 SGD PMID 10330137

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