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Systematic name YGR023W
Gene name MTL1
Feature type ORF, Verified
Coordinates Chr VII:529264..530919
Primary SGDID S000003255

Description of YGR023W: Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p[1][2][3]


Community Commentary

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Transmembrane Domain GxxxG

The transmembrane domain of Mtl1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with iiiGcvvG. The presence of a GxxxG motif [4] strongly indicates that Mtl1p dimerises.



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  1. Ketela T, et al. (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40 SGD PMID 10348843
  2. Rajavel M, et al. (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol 19(6):3969-76 SGD PMID 10330137
  3. Vilella F, et al. (2005) Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J Biol Chem 280(10):9149-59 SGD PMID 15637049
  4. Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242

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