YDR477W
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| Systematic name | YDR477W | |
| Gene name | SNF1 | |
| Aliases | CAT1, CCR1, GLC2, HAF3, PAS14 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr IV:1412365..1414266 | |
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Description of YDR477W: AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis[1][2]
Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Strain Background: Sigma1278b
Genotype: MCY4461
Together with: REG1
Phenotype(s): Loss of function (Null)
Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. [3] [4]
Interactions
Genetic
YDR477W is suppressed by Nrg2
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg2 partially suppresses Snf1's defect in invasive growth, biofilm formation, FLO11 expression, and STA2 expression. [3] [5]
YDR477W is suppressed by Nrg1
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg1 partially suppresses Snf1's defect in invasive growth, FLO11 expression, and STA2 expression. [3] [5]
Physical
Physical interaction with Nrg2
Snf1 coimmunoprecipitates with HA3-Nrg2 [6] [5]
Physical interaction with Nrg2
LexA-Snf1 coimmunoprecipitates HA3-Nrg2 [6] [5]
Physical interaction with Nrg1
Snf1 coimmunoprecipitates with HA3-Nrg1 [6] [5]
Physical interaction with Nrg1
LexA-Snf1 coimmunoprecipitates HA3-Nrg1 [6] [5]
Two Hybrid
Two Hybrid interaction with Nrg2
Snf1 kinase domain interacts with Nrg2 [6] [5]
Two Hybrid interaction with nrg1
Snf1 kinase domain interacts with Nrg1 [6] [5]
Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Strain Background: Sigma1278b
Genotype: MCY4461
Together with: REG1
Phenotype(s): Loss of function (Null)
Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. [3] [4]
Interactions
Genetic
YDR477W is suppressed by Nrg2
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg2 partially suppresses Snf1's defect in invasive growth, biofilm formation, FLO11 expression, and STA2 expression. [3] [5]
YDR477W is suppressed by Nrg1
Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion
Deletion of Nrg1 partially suppresses Snf1's defect in invasive growth, FLO11 expression, and STA2 expression. [3] [5]
Physical
Physical interaction with Nrg2
Snf1 coimmunoprecipitates with HA3-Nrg2 [6] [5]
Physical interaction with Nrg2
LexA-Snf1 coimmunoprecipitates HA3-Nrg2 [6] [5]
Physical interaction with Nrg1
Snf1 coimmunoprecipitates with HA3-Nrg1 [6] [5]
Physical interaction with Nrg1
LexA-Snf1 coimmunoprecipitates HA3-Nrg1 [6] [5]
Two Hybrid
Two Hybrid interaction with Nrg2
Snf1 kinase domain interacts with Nrg2 [6] [5]
Two Hybrid interaction with nrg1
Snf1 kinase domain interacts with Nrg1 [6] [5]
References
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- ↑ Hardie DG, et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67():821-55 SGD PMID 9759505
- ↑ Sanz P (2003) Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem Soc Trans 31(Pt 1):178-81 SGD PMID 12546680
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 SGD PMID 12024013
- ↑ 4.0 4.1 submitted by Valmik K. Vyas on 2003-03-27
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 submitted by Valmik K. Vyas on 2003-02-04
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 SGD PMID 11404322
See Help:Categories on how to add the wiki page for this gene to a Category
- ORF
- ORF, Verified
- Topic:Alleles, Strains, and Phenotypes
- Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains
- Phenotype:Loss of function (Null)
- Topic:Interactions
- Topic:Interactions:Genetic
- Genetic Interaction with Nrg2
- Genetic Interaction with Nrg1
- Topic:Interactions:Physical
- Physical Interactions with Nrg2
- Physical Interactions with Nrg1
- Topic:Interactions:Two Hybrid
- Two Hybrid Interactions with Nrg2
- Two Hybrid Interactions with nrg1
