YHR157W
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| Systematic name | YHR157W |
| Gene name | REC104 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:412910..413458 |
| Primary SGDID | S000001200 |
Description of YHR157W: Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination[1][2][3]
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Contents
Community Commentary
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Interactions
Physical
Physical interaction with Rec102
Immunoprecipitation and two-hybrid interactions. Both proteins are mutually interdependent for nuclear localization and association with meiotic chromosomes, and both also depend on Spo11p and Ski8p for chromatin association. [4] [5]
Two Hybrid
Two Hybrid interaction with Spo11
meiosis-specific two hybrid interaction requires presence of endogenous SKI8 and REC102 genes [6] [7]
Two Hybrid interaction with Rec114
[6] [7]
Protein Details
Protein Localization
Nuclear localization and association with meiotic chromosomes are dependent on Rec102p. Chromatin association ends abruptly during the pachytene stage of meiosis. [4] [5]
Protein Modification
Modification(s): Phosphorylation
Normal phosphorylation of Rec104p requires the presence of its protein interaction partner, Rec102p. [4] [5]
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References
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- ↑ Jiao K, et al. (2003) Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p. Mol Cell Biol 23(16):5928-38 SGD PMID 12897161
- ↑ Malone RE, et al. (1991) Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 128(1):79-88 SGD PMID 2060778
- ↑ Galbraith AM and Malone RE (1992) Characterization of REC104, a gene required for early meiotic recombination in the yeast Saccharomyces cerevisiae. Dev Genet 13(6):392-402 SGD PMID 1304422
- ↑ 4.0 4.1 4.2 Kee K, et al. (2004) Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8):1815-24 SGD PMID 15044957
- ↑ 5.0 5.1 5.2 submitted by Scott Keeney on 2005-12-09
- ↑ 6.0 6.1 Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 SGD PMID 14992724
- ↑ 7.0 7.1 submitted by Scott Keeney on 2004-05-02
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
- ORF
- ORF, Verified
- Topic:Interactions
- Topic:Interactions:Physical
- Physical Interactions with Rec102
- Topic:Interactions:Two Hybrid
- Two Hybrid Interactions with Spo11
- Two Hybrid Interactions with Rec114
- Topic:Protein Details
- Topic:Protein Details:Protein Localization
- Topic:Protein Details:Protein Modification
- Modification:Phosphorylation
