YER069W

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Systematic name YER069W
Gene name ARG5,6
Aliases
Feature type ORF, Verified
Coordinates Chr V:295408..297999


Description of YER069W: Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p[1][2][3]




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Protein Details

Other Protein Details

Other Topic: Processing

Mass spectrometry analyses of Arg5p (52 kDa) & Arg6p (32 kDa) yielded peptides spanning amino acids 90-444 (Arg5p) & 555-859 (Arg6p). [4] [5]


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References

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  1. Abadjieva A, et al. (2001) A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase. J Biol Chem 276(46):42869-80 SGD PMID 11553611
  2. Boonchird C, et al. (1991) Characterization of the yeast ARG5,6 gene: determination of the nucleotide sequence, analysis of the control region and of ARG5,6 transcript. Mol Gen Genet 226(1-2):154-66 SGD PMID 1851947
  3. Boonchird C, et al. (1991) Determination of amino acid sequences involved in the processing of the ARG5/ARG6 precursor in Saccharomyces cerevisiae. Eur J Biochem 199(2):325-35 SGD PMID 1649049
  4. Ohlmeier S, et al. (2004) The yeast mitochondrial proteome, a study of fermentative and respiratory growth. J Biol Chem 279(6):3956-79 SGD PMID 14597615
  5. submitted by Steffen Ohlmeier on 2004-04-08

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