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Systematic name YER069W
Gene name ARG5,6
Feature type ORF, Verified
Coordinates Chr V:295410..298001
Primary SGDID S000000871

Description of YER069W: Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine[1][2][3][4]


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Protein Details

Other Protein Details

Other Topic: Processing

Mass spectrometry analyses of Arg5p (52 kDa) & Arg6p (32 kDa) yielded peptides spanning amino acids 90-444 (Arg5p) & 555-859 (Arg6p). [5] [6]



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  1. Abadjieva A, et al. (2001) A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase. J Biol Chem 276(46):42869-80 SGD PMID 11553611
  2. Boonchird C, et al. (1991) Characterization of the yeast ARG5,6 gene: determination of the nucleotide sequence, analysis of the control region and of ARG5,6 transcript. Mol Gen Genet 226(1-2):154-66 SGD PMID 1851947
  3. Boonchird C, et al. (1991) Determination of amino acid sequences involved in the processing of the ARG5/ARG6 precursor in Saccharomyces cerevisiae. Eur J Biochem 199(2):325-35 SGD PMID 1649049
  4. de Cima S, et al. (2012) Insight on an arginine synthesis metabolon from the tetrameric structure of yeast acetylglutamate kinase. PLoS One 7(4):e34734 SGD PMID 22529931
  5. Ohlmeier S, et al. (2004) The yeast mitochondrial proteome, a study of fermentative and respiratory growth. J Biol Chem 279(6):3956-79 SGD PMID 14597615
  6. submitted by Steffen Ohlmeier on 2004-04-08

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