Difference between revisions of "YLL040C"
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| − | '''Description of YLL040C:''' Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes | + | '''Description of YLL040C:''' Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively<ref name='S000047092'>Brickner JH and Fuller RS (1997) SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals. J Cell Biol 139(1):23-36 {{SGDpaper|S000047092}} PMID 9314526</ref><ref name='S000148967'>Park JS and Neiman AM (2012) VPS13 Regulates Membrane Morphogenesis During Sporulation in Saccharomyces cerevisiae. J Cell Sci () {{SGDpaper|S000148967}} PMID 22442115</ref><ref name='S000043240'>Redding K, et al. (1996) Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins. Mol Cell Biol 16(11):6208-17 |
{{SGDpaper|S000043240}} PMID 8887651</ref> | {{SGDpaper|S000043240}} PMID 8887651</ref> | ||
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Latest revision as of 13:05, 24 April 2012
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| Systematic name | YLL040C |
| Gene name | VPS13 |
| Aliases | SOI1, VPT2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:63645..54211 |
| Primary SGDID | S000003963 |
Description of YLL040C: Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively[1][2][3]
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Protein Details
Protein Localization
Vps13p acts in a positive way on TLS1 retrieval from the PVC to the TGN [1] [4]
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References
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- ↑ 1.0 1.1 Brickner JH and Fuller RS (1997) SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals. J Cell Biol 139(1):23-36 SGD PMID 9314526
- ↑ Park JS and Neiman AM (2012) VPS13 Regulates Membrane Morphogenesis During Sporulation in Saccharomyces cerevisiae. J Cell Sci () SGD PMID 22442115
- ↑ Redding K, et al. (1996) Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins. Mol Cell Biol 16(11):6208-17 SGD PMID 8887651
- ↑ submitted by EJ Brace on 2003-08-13
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