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Systematic name YLL040C
Gene name VPS13
Aliases SOI1, VPT2
Feature type ORF, Verified
Coordinates Chr XII:63645..54211
Primary SGDID S000003963

Description of YLL040C: Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively[1][2][3]


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Protein Details

Protein Localization

Vps13p acts in a positive way on TLS1 retrieval from the PVC to the TGN [1] [4]



See Help:References on how to add references

  1. 1.0 1.1 Brickner JH and Fuller RS (1997) SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals. J Cell Biol 139(1):23-36 SGD PMID 9314526
  2. Park JS and Neiman AM (2012) VPS13 Regulates Membrane Morphogenesis During Sporulation in Saccharomyces cerevisiae. J Cell Sci () SGD PMID 22442115
  3. Redding K, et al. (1996) Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins. Mol Cell Biol 16(11):6208-17 SGD PMID 8887651
  4. submitted by EJ Brace on 2003-08-13

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