Difference between revisions of "YFL036W"
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| − | '''Description of YFL036W:''' Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition | + | '''Description of YFL036W:''' Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; binding of Mtf1p to the Rpo41p-promoter complex stabilizes the binding and induces DNA bending<ref name='S000050238'>Greenleaf AL, et al. (1986) Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A 83(10):3391-4 {{SGDpaper|S000050238}} PMID 3517858</ref><ref name='S000146745'>Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () |
| − | {{SGDpaper| | + | {{SGDpaper|S000146745}} PMID 21911502</ref> |
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Revision as of 13:05, 5 October 2011
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| Systematic name | YFL036W |
| Gene name | RPO41 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:58782..62837 |
| Primary SGDID | S000001858 |
Description of YFL036W: Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; binding of Mtf1p to the Rpo41p-promoter complex stabilizes the binding and induces DNA bending[1][2]
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Contents
Community Commentary
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Interactions
Two Hybrid
Two Hybrid interaction with MTF2
The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. [3] [4]
Protein Details
Protein Function/Process
The amino-terminal extension of Rpo41p contains a functional domain that is dispensible for transcription initiation, but is required for mtDNA stability, suggesting that additional activities are coupled to transcription during mitochondrial gene expression and/or mtDNA replication. [5] [6]
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References
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- ↑ Greenleaf AL, et al. (1986) Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A 83(10):3391-4 SGD PMID 3517858
- ↑ Tang GQ, et al. (2011) Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. J Biol Chem () SGD PMID 21911502
- ↑ Rodeheffer MS, et al. (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22 SGD PMID 11118450
- ↑ submitted by Gerald Shadel on 2003-06-05
- ↑ Wang Y and Shadel GS (1999) Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A 96(14):8046-51 SGD PMID 10393945
- ↑ submitted by Gerald Shadel on 2003-06-06
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