Difference between revisions of "YKL049C"
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| − | '''Description of YKL049C:''' Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A<ref name='S000039973'>Meluh PB, et al. (1998) Cse4p is a component of the core centromere of Saccharomyces cerevisiae. Cell 94(5):607-13 {{SGDpaper|S000039973}} PMID 9741625</ref><ref name='S000046262'>Stoler S, et al. (1995) A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Genes Dev 9(5):573-86 | + | '''Description of YKL049C:''' Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p<ref name='S000140160'>Hewawasam G, et al. (2010) Psh1 Is an E3 Ubiquitin Ligase that Targets the Centromeric Histone Variant Cse4. Mol Cell 40(3):444-54 {{SGDpaper|S000140160}} PMID 21070970</ref><ref name='S000039973'>Meluh PB, et al. (1998) Cse4p is a component of the core centromere of Saccharomyces cerevisiae. Cell 94(5):607-13 {{SGDpaper|S000039973}} PMID 9741625</ref><ref name='S000140159'>Ranjitkar P, et al. (2010) An E3 Ubiquitin Ligase Prevents Ectopic Localization of the Centromeric Histone H3 Variant via the Centromere Targeting Domain. Mol Cell 40(3):455-64 {{SGDpaper|S000140159}} PMID 21070971</ref><ref name='S000046262'>Stoler S, et al. (1995) A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Genes Dev 9(5):573-86 |
{{SGDpaper|S000046262}} PMID 7698647</ref> | {{SGDpaper|S000046262}} PMID 7698647</ref> | ||
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Revision as of 13:05, 21 January 2011
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| Systematic name | YKL049C |
| Gene name | CSE4 |
| Aliases | CSL2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:346408..345719 |
| Primary SGDID | S000001532 |
Description of YKL049C: Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p[1][2][3][4]
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Community Commentary
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Interactions
Physical
Physical interaction with NNF1
Cse4p immunoprecipitates with Nnf1p. [5] [6]
Physical interaction with MTW1
Cse4p co-immunoprecipitates with Mtw1p. [5] [6]
Physical interaction with DSN1
Cse4p co-immunopreciptates with Dsn1p. [5] [6]
Physical interaction with MIF2
Cse4p immunoprecipitates with Mif2p. [5] [6]
Physical interaction with NSL1
Cse4p immunoprecipitates with Nsl1p. [5] [6]
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References
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- ↑ Hewawasam G, et al. (2010) Psh1 Is an E3 Ubiquitin Ligase that Targets the Centromeric Histone Variant Cse4. Mol Cell 40(3):444-54 SGD PMID 21070970
- ↑ Meluh PB, et al. (1998) Cse4p is a component of the core centromere of Saccharomyces cerevisiae. Cell 94(5):607-13 SGD PMID 9741625
- ↑ Ranjitkar P, et al. (2010) An E3 Ubiquitin Ligase Prevents Ectopic Localization of the Centromeric Histone H3 Variant via the Centromere Targeting Domain. Mol Cell 40(3):455-64 SGD PMID 21070971
- ↑ Stoler S, et al. (1995) A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Genes Dev 9(5):573-86 SGD PMID 7698647
- ↑ 5.0 5.1 5.2 5.3 5.4 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
- ↑ 6.0 6.1 6.2 6.3 6.4 submitted by Benjamin Pinsky on 2004-03-04
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