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Systematic name YKL049C
Gene name CSE4
Aliases CSL2
Feature type ORF, Verified
Coordinates Chr XI:346764..346075
Primary SGDID S000001532

Description of YKL049C: Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p[1][2][3][4]


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Physical interaction with NNF1
Cse4p immunoprecipitates with Nnf1p. [5] [6]

Physical interaction with MTW1
Cse4p co-immunoprecipitates with Mtw1p. [5] [6]

Physical interaction with DSN1
Cse4p co-immunopreciptates with Dsn1p. [5] [6]

Physical interaction with MIF2
Cse4p immunoprecipitates with Mif2p. [5] [6]

Physical interaction with NSL1
Cse4p immunoprecipitates with Nsl1p. [5] [6]



See Help:References on how to add references

  1. Hewawasam G, et al. (2010) Psh1 Is an E3 Ubiquitin Ligase that Targets the Centromeric Histone Variant Cse4. Mol Cell 40(3):444-54 SGD PMID 21070970
  2. Meluh PB, et al. (1998) Cse4p is a component of the core centromere of Saccharomyces cerevisiae. Cell 94(5):607-13 SGD PMID 9741625
  3. Ranjitkar P, et al. (2010) An E3 Ubiquitin Ligase Prevents Ectopic Localization of the Centromeric Histone H3 Variant via the Centromere Targeting Domain. Mol Cell 40(3):455-64 SGD PMID 21070971
  4. Stoler S, et al. (1995) A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Genes Dev 9(5):573-86 SGD PMID 7698647
  5. 5.0 5.1 5.2 5.3 5.4 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
  6. 6.0 6.1 6.2 6.3 6.4 submitted by Benjamin Pinsky on 2004-03-04

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