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| − | === Interactions ===
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| − | [[Category:Topic:Interactions]]
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| − | ==== Two Hybrid ====
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| − | [[Category:Topic:Interactions:Two Hybrid]]
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| − | Two Hybrid interaction with Prp40 [[Category:Two Hybrid Interactions with Prp40]]<br>
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| − | Prp8 interacts with the U1snRNP protein Prp40 <ref name='S000040368'>Abovich N and Rosbash M (1997) Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell 89(3):403-12 {{SGDpaper|S000040368}} PMID 9150140</ref> <ref name = 'CAset9267-2003-04-11'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9267 Richard Grainger] on 2003-04-11</ref>
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| − | {{ShortCenteredHR}}
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| − | Two Hybrid interaction with Snp1 [[Category:Two Hybrid Interactions with Snp1]]<br>
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| − | Prp8 interacts with the U1snRNP protein Snp1 <ref name='S000069169'>Awasthi S, et al. (2001) New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. J Biol Chem 276(33):31004-15 {{SGDpaper|S000069169}} PMID 11425851</ref> <ref name = 'CAset9267-2003-04-11'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9267 Richard Grainger] on 2003-04-11</ref>
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| − | {{ShortCenteredHR}}
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| − | Two Hybrid interaction with Exo84 [[Category:Two Hybrid Interactions with Exo84]]<br>
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| − | Prp8 binds to C-terminus of Exo84 <ref name='S000052181'>Kuhn AN and Brow DA (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155(4):1667-82 {{SGDpaper|S000052181}} PMID 10924465</ref> <ref name = 'CAset9267-2003-04-11'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9267 Richard Grainger] on 2003-04-11</ref>
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| − | {{ShortCenteredHR}}
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| − | Two Hybrid interaction with Prp39 [[Category:Two Hybrid Interactions with Prp39]]<br>
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| − | N-terminal region of Prp8 interacts with Prp39 <ref name='S000060204'>van Nues RW and Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67 {{SGDpaper|S000060204}} PMID 11290703</ref> <ref name = 'CAset9267-2003-04-11'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9267 Richard Grainger] on 2003-04-11</ref>
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| − |
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| − | {{ShortCenteredHR}}
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| − | Two Hybrid interaction with Brr2 [[Category:Two Hybrid Interactions with Brr2]]<br>
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| − | C-terminus of Prp8 binds to full length Brr2. N-terminus of Prp8 binds to Prp39 <ref name='S000060204'>van Nues RW and Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67 {{SGDpaper|S000060204}} PMID 11290703</ref> <ref name = 'CAset9267-2003-04-11'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9267 Richard Grainger] on 2003-04-11</ref>
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| − | {{ShortCenteredHR}}
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| | __TOC__ | | __TOC__ |
| | ==Community Commentary== | | ==Community Commentary== |
Revision as of 10:51, 24 January 2007
Share your knowledge...Edit this entry!
| Systematic name |
YHR165C
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| Gene name |
PRP8
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| Aliases |
DBF3, DNA39, RNA8, SLT21, USA2
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| Feature type |
ORF, Verified
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| Coordinates
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Chr VIII:436950..429709
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Description of YHR165C: Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing[1][2]
About Community Commentary. Please share your knowledge!
Interactions
Two Hybrid
Two Hybrid interaction with Prp40
Prp8 interacts with the U1snRNP protein Prp40 [3] [4]
Two Hybrid interaction with Snp1
Prp8 interacts with the U1snRNP protein Snp1 [5] [4]
Two Hybrid interaction with Exo84
Prp8 binds to C-terminus of Exo84 [6] [4]
Two Hybrid interaction with Prp39
N-terminal region of Prp8 interacts with Prp39 [7] [4]
Two Hybrid interaction with Brr2
C-terminus of Prp8 binds to full length Brr2. N-terminus of Prp8 binds to Prp39 [7] [4]
References
See Help:References on how to add references
- ↑ Umen JG and Guthrie C (1995) The second catalytic step of pre-mRNA splicing. RNA 1(9):869-85 SGD PMID 8548652
- ↑ Stevens SW and Abelson J (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31
SGD PMID 10377396
- ↑ Abovich N and Rosbash M (1997) Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell 89(3):403-12 SGD PMID 9150140
- ↑ 4.0 4.1 4.2 4.3 4.4 submitted by Richard Grainger on 2003-04-11
- ↑ Awasthi S, et al. (2001) New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. J Biol Chem 276(33):31004-15 SGD PMID 11425851
- ↑ Kuhn AN and Brow DA (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155(4):1667-82 SGD PMID 10924465
- ↑ 7.0 7.1 van Nues RW and Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67 SGD PMID 11290703
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