Difference between revisions of "YBL098W"
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| − | '''Description of YBL098W:''' Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease<ref name=' | + | '''Description of YBL098W:''' Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease<ref name='S000074280'>Bedalov A, et al. (2003) NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Mol Cell Biol 23(19):7044-54 {{SGDpaper|S000074280}} PMID 12972620</ref><ref name='S000081352'>Giorgini F, et al. (2005) A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet 37(5):526-31 {{SGDpaper|S000081352}} PMID 15806102</ref><ref name='S000069977'>Panozzo C, et al. (2002) Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett 517(1-3):97-102 |
| − | {{SGDpaper| | + | {{SGDpaper|S000069977}} PMID 12062417</ref> |
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Revision as of 13:05, 25 February 2010
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| Systematic name | YBL098W |
| Gene name | BNA4 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:39142..40524 |
| Primary SGDID | S000000194 |
Description of YBL098W: Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease[1][2][3]
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References
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- ↑ Bedalov A, et al. (2003) NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Mol Cell Biol 23(19):7044-54 SGD PMID 12972620
- ↑ Giorgini F, et al. (2005) A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet 37(5):526-31 SGD PMID 15806102
- ↑ Panozzo C, et al. (2002) Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett 517(1-3):97-102 SGD PMID 12062417
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