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Systematic name YBL098W
Gene name BNA4
Feature type ORF, Verified
Coordinates Chr II:39145..40527
Primary SGDID S000000194

Description of YBL098W: Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease[1][2][3]


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  1. Bedalov A, et al. (2003) NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Mol Cell Biol 23(19):7044-54 SGD PMID 12972620
  2. Giorgini F, et al. (2005) A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet 37(5):526-31 SGD PMID 15806102
  3. Panozzo C, et al. (2002) Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett 517(1-3):97-102 SGD PMID 12062417

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