Difference between revisions of "YAL024C"
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| − | '''Description of YAL024C:''' | + | '''Description of YAL024C:''' Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures<ref name='S000052520'>Shirayama M, et al. (1994) Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1. Yeast 10(4):451-61 {{SGDpaper|S000052520}} PMID 7941731</ref><ref name='S000132413'>Geymonat M, et al. (2009) Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1. J Cell Biol 187(4):497-511 |
| − | {{SGDpaper| | + | {{SGDpaper|S000132413}} PMID 19948498</ref> |
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Revision as of 13:05, 10 December 2009
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| Systematic name | YAL024C |
| Gene name | LTE1 |
| Aliases | MSI2 |
| Feature type | ORF, Verified |
| Coordinates | Chr I:105873..101566 |
| Primary SGDID | S000000022 |
Description of YAL024C: Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures[1][2]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]
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References
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- ↑ Shirayama M, et al. (1994) Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1. Yeast 10(4):451-61 SGD PMID 7941731
- ↑ Geymonat M, et al. (2009) Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1. J Cell Biol 187(4):497-511 SGD PMID 19948498
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-21
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