YAL024C

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Systematic name YAL024C
Gene name LTE1
Aliases MSI2
Feature type ORF, Verified
Coordinates Chr I:105872..101565
Primary SGDID S000000022


Description of YAL024C: Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures[1][2]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]





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References

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  1. Geymonat M, et al. (2009) Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1. J Cell Biol 187(4):497-511 SGD PMID 19948498
  2. Shirayama M, et al. (1994) Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1. Yeast 10(4):451-61 SGD PMID 7941731
  3. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  4. submitted by Jeff Ubersax on 2004-01-21

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