Difference between revisions of "YFR027W"
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| − | '''Description of YFR027W:''' Acetyltransferase | + | '''Description of YFR027W:''' Acetyltransferase that modifies cohesin subunit Smc3p, promoting sister chromatid cohesion during S phase; generates double-strand break repair induced cohesion by acetylating cohesin subunit Mcd1p; acetylated substrates antagonize Wpl1p<ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 {{SGDpaper|S000049775}} PMID 9990855</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000123318'>Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 {{SGDpaper|S000123318}} PMID 17626885</ref><ref name='S000126972'>Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51 {{SGDpaper|S000126972}} PMID 18614053</ref><ref name='S000127160'>Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 {{SGDpaper|S000127160}} PMID 18653894</ref><ref name='S000127161'>Ben-Shahar TR, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 {{SGDpaper|S000127161}} PMID 18653893</ref><ref name='S000130406'>Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 |
| − | {{SGDpaper| | + | {{SGDpaper|S000130406}} PMID 19450529</ref> |
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Revision as of 14:05, 2 June 2009
Share your knowledge...Edit this entry! <protect>
| Systematic name | YFR027W |
| Gene name | ECO1 |
| Aliases | CTF7 |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:207440..208285 |
| Primary SGDID | S000001923 |
Description of YFR027W: Acetyltransferase that modifies cohesin subunit Smc3p, promoting sister chromatid cohesion during S phase; generates double-strand break repair induced cohesion by acetylating cohesin subunit Mcd1p; acetylated substrates antagonize Wpl1p[1][2][3][4][5][6][7][8]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [9] [10]
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References
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- ↑ Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 SGD PMID 9990855
- ↑ Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 SGD PMID 9990856
- ↑ Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 SGD PMID 11448778
- ↑ Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 SGD PMID 17626885
- ↑ Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51 SGD PMID 18614053
- ↑ Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 SGD PMID 18653894
- ↑ Ben-Shahar TR, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 SGD PMID 18653893
- ↑ Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 SGD PMID 19450529
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-27
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