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Systematic name YFR027W
Gene name ECO1
Aliases CTF7
Feature type ORF, Verified
Coordinates Chr VI:207452..208297
Primary SGDID S000001923

Description of YFR027W: Acetyltransferase required for establishment of sister chromatid cohesion; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome[1][2][3][4][5][6][7][8][9][10][11]


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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [12] [13]



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  1. Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 SGD PMID 19450529
  2. Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 SGD PMID 16962805
  3. Onn I, et al. (2009) The zinc finger of Eco1 enhances its acetyltransferase activity during sister chromatid cohesion. Nucleic Acids Res 37(18):6126-34 SGD PMID 19692582
  4. Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 SGD PMID 18653893
  5. Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 SGD PMID 11448778
  6. Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 SGD PMID 9990855
  7. Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 SGD PMID 9990856
  8. Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 SGD PMID 17626885
  9. Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 SGD PMID 18653894
  10. Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 SGD PMID 15821733
  11. Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51 SGD PMID 18614053
  12. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  13. submitted by Jeff Ubersax on 2004-01-27

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