YFR027W

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Systematic name YFR027W
Gene name ECO1
Aliases CTF7
Feature type ORF, Verified
Coordinates Chr VI:207452..208297
Primary SGDID S000001923


Description of YFR027W: Acetyltransferase required for establishment of sister chromatid cohesion; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome[1][2][3][4][5][6][7][8][9][10][11]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [12] [13]





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References

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  1. Jump up Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 SGD PMID 19450529
  2. Jump up Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 SGD PMID 16962805
  3. Jump up Onn I, et al. (2009) The zinc finger of Eco1 enhances its acetyltransferase activity during sister chromatid cohesion. Nucleic Acids Res 37(18):6126-34 SGD PMID 19692582
  4. Jump up Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 SGD PMID 18653893
  5. Jump up Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 SGD PMID 11448778
  6. Jump up Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 SGD PMID 9990855
  7. Jump up Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 SGD PMID 9990856
  8. Jump up Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 SGD PMID 17626885
  9. Jump up Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 SGD PMID 18653894
  10. Jump up Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 SGD PMID 15821733
  11. Jump up Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51 SGD PMID 18614053
  12. Jump up Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  13. Jump up submitted by Jeff Ubersax on 2004-01-27

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