Difference between revisions of "YMR234W"

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'''Description of YMR234W:''' Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand<ref name='S000074165'>Itaya M, et al. (1991) Selective cloning of genes encoding RNase H from Salmonella typhimurium, Saccharomyces cerevisiae and Escherichia coli rnh mutant. Mol Gen Genet 227(3):438-45 {{SGDpaper|S000074165}} PMID 1650910</ref><ref name='S000074164'>Crouch RJ (1990) Ribonuclease H: from discovery to 3D structure. New Biol 2(9):771-7 {{SGDpaper|S000074164}} PMID 2177653</ref><ref name='S000058459'>Waga S and Stillman B (1998) The DNA replication fork in eukaryotic cells. Annu Rev Biochem 67():721-51
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'''Description of YMR234W:''' Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)<ref name='S000116187'>Huet J, et al. (1977) Characterization of ribonuclease H activity associated yeast RNA polymerase A. J Biol Chem 252(24):8848-55 {{SGDpaper|S000116187}} PMID 21884</ref><ref name='S000074165'>Itaya M, et al. (1991) Selective cloning of genes encoding RNase H from Salmonella typhimurium, Saccharomyces cerevisiae and Escherichia coli rnh mutant. Mol Gen Genet 227(3):438-45 {{SGDpaper|S000074165}} PMID 1650910</ref><ref name='S000058485'>Cerritelli SM and Crouch RJ (1995) The non-RNase H domain of Saccharomyces cerevisiae RNase H1 binds double-stranded RNA: magnesium modulates the switch between double-stranded RNA binding and RNase H activity. RNA 1(3):246-59
  {{SGDpaper|S000058459}} PMID 9759502</ref>
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  {{SGDpaper|S000058485}} PMID 7489497</ref>
 
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Revision as of 06:21, 26 February 2009

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Systematic name YMR234W
Gene name RNH1
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:740265..741311
Primary SGDID S000004847


Description of YMR234W: Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)[1][2][3]




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References

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  1. Huet J, et al. (1977) Characterization of ribonuclease H activity associated yeast RNA polymerase A. J Biol Chem 252(24):8848-55 SGD PMID 21884
  2. Itaya M, et al. (1991) Selective cloning of genes encoding RNase H from Salmonella typhimurium, Saccharomyces cerevisiae and Escherichia coli rnh mutant. Mol Gen Genet 227(3):438-45 SGD PMID 1650910
  3. Cerritelli SM and Crouch RJ (1995) The non-RNase H domain of Saccharomyces cerevisiae RNase H1 binds double-stranded RNA: magnesium modulates the switch between double-stranded RNA binding and RNase H activity. RNA 1(3):246-59 SGD PMID 7489497

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