Difference between revisions of "YHL020C"
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| − | '''Description of YHL020C:''' Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance<ref name=' | + | '''Description of YHL020C:''' Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance<ref name='S000073253'>Sreenivas A and Carman GM (2003) Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase A. J Biol Chem 278(23):20673-80 {{SGDpaper|S000073253}} PMID 12668681</ref><ref name='S000074120'>Santiago TC and Mamoun CB (2003) Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. J Biol Chem 278(40):38723-30 {{SGDpaper|S000074120}} PMID 12871953</ref><ref name='S000114270'>Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 |
| − | {{SGDpaper| | + | {{SGDpaper|S000114270}} PMID 15161972</ref> |
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Revision as of 03:40, 18 December 2008
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| Systematic name | YHL020C |
| Gene name | OPI1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:67453..66239 |
| Primary SGDID | S000001012 |
Description of YHL020C: Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance[1][2][3]
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Community Commentary
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Protein Details
Protein Function/Process
Phosphatidic acid on the endoplasmic reticulum directly binds to soluble Opi1p to maintain it as inactive outside the nucleus. After the addition of the lipid precursor inositol, this phosphatidic acid is rapidly consumed, releasing Opi1p from the endoplasmic reticulum and allowing its nuclear translocation and repression of target genes. [4] [5]
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References
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- ↑ Sreenivas A and Carman GM (2003) Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase A. J Biol Chem 278(23):20673-80 SGD PMID 12668681
- ↑ Santiago TC and Mamoun CB (2003) Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. J Biol Chem 278(40):38723-30 SGD PMID 12871953
- ↑ Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
- ↑ Loewen CJ, et al. (2004) Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science 304(5677):1644-7 SGD PMID 15192221
- ↑ submitted by Peter Uetz on 2005-10-28
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