From SGD-Wiki
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YHL020C
Gene name OPI1
Feature type ORF, Verified
Coordinates Chr VIII:67456..66242
Primary SGDID S000001012

Description of YHL020C: Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance[1][2][3]


Community Commentary

About Community Commentary. Please share your knowledge!

Protein Details

Protein Function/Process

Phosphatidic acid on the endoplasmic reticulum directly binds to soluble Opi1p to maintain it as inactive outside the nucleus. After the addition of the lipid precursor inositol, this phosphatidic acid is rapidly consumed, releasing Opi1p from the endoplasmic reticulum and allowing its nuclear translocation and repression of target genes. [4] [5]



See Help:References on how to add references

  1. Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. Santiago TC and Mamoun CB (2003) Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. J Biol Chem 278(40):38723-30 SGD PMID 12871953
  3. Sreenivas A and Carman GM (2003) Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase A. J Biol Chem 278(23):20673-80 SGD PMID 12668681
  4. Loewen CJ, et al. (2004) Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science 304(5677):1644-7 SGD PMID 15192221
  5. submitted by Peter Uetz on 2005-10-28

See Help:Categories on how to add the wiki page for this gene to a Category </protect>