Difference between revisions of "YDR227W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002635 YDR227W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SIR4 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SIR4 '' | ||
Latest revision as of 06:45, 23 January 2012
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| Systematic name | YDR227W |
| Gene name | SIR4 |
| Aliases | ASD1, STE9, UTH2 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:917571..921647 |
| Primary SGDID | S000002635 |
Description of YDR227W: Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan[1][2][3]
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Contents
Community Commentary
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Interactions
Two Hybrid
Two Hybrid interaction with UBP10
The N-terminal 250 aa of Ubp10p interacts with the C-terminus of Sir4p (residues 839-1358). [4] [5]
Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [6]
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References
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- ↑ Kennedy BK, et al. (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80(3):485-96 SGD PMID 7859289
- ↑ Moazed D, et al. (1997) Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci U S A 94(6):2186-91 SGD PMID 9122169
- ↑ 3.0 3.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ Kahana A and Gottschling DE (1999) DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6608-20 SGD PMID 10490600
- ↑ submitted by Daniel E. Gottschling on 2003-03-17
- ↑ submitted by Jeff Ubersax on 2004-01-21
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