Difference between revisions of "YPR068C"

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|nowrap| Chr XVI:684350..682938
 
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==Community Commentary==
 
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==References==
 
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Revision as of 07:18, 30 January 2007

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Systematic name YPR068C
Gene name HOS1
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:684350..682938


Description of YPR068C: Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex[1][2][3]




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Community Commentary

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Protein Details

Protein Function/Process

In Robyr et al (2002), antibodies to specific acetyl forms of histones were used to find regions of the genome that increased in acetylation when certain histone deacetylases were deleted. Deletion of Hos1 resulted in increased acetylation primarily at the rDNA repeats. [2] [4]


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References

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  1. Davie JK, et al. (2003) Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62 SGD PMID 14525981
  2. 2.0 2.1 Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 SGD PMID 12086601
  3. Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 SGD PMID 8962081
  4. submitted by Hunter Fraser on 2003-04-18

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