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Systematic name YPR068C
Gene name HOS1
Feature type ORF, Verified
Coordinates Chr XVI:684353..682941
Primary SGDID S000006272

Description of YPR068C: Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex[1][2][3][4][5]


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Protein Details

Protein Function/Process

In Robyr et al (2002), antibodies to specific acetyl forms of histones were used to find regions of the genome that increased in acetylation when certain histone deacetylases were deleted. Deletion of Hos1 resulted in increased acetylation primarily at the rDNA repeats. [3] [6]



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  1. Borges V, et al. (2010) Hos1 deacetylates smc3 to close the cohesin acetylation cycle. Mol Cell 39(5):677-88 SGD PMID 20832720
  2. Davie JK, et al. (2003) Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62 SGD PMID 14525981
  3. 3.0 3.1 Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 SGD PMID 12086601
  4. Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 SGD PMID 8962081
  5. Xiong B, et al. (2010) Hos1 is a lysine deacetylase for the smc3 subunit of cohesin. Curr Biol 20(18):1660-5 SGD PMID 20797861
  6. submitted by Hunter Fraser on 2003-04-18

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