Difference between revisions of "YPR068C"
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| − | '''Description of YPR068C:''' | + | '''Description of YPR068C:''' Class I histone deacetylase (HDAC) family member that also deacetylates Smc3p at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex<ref name='S000136515'>Borges V, et al. (2010) Hos1 deacetylates smc3 to close the cohesin acetylation cycle. Mol Cell 39(5):677-88 {{SGDpaper|S000136515}} PMID 20832720</ref><ref name='S000075178'>Davie JK, et al. (2003) Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62 {{SGDpaper|S000075178}} PMID 14525981</ref><ref name='S000070188'>Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 {{SGDpaper|S000070188}} PMID 12086601</ref><ref name='S000047708'>Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 |
{{SGDpaper|S000047708}} PMID 8962081</ref> | {{SGDpaper|S000047708}} PMID 8962081</ref> | ||
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Revision as of 13:05, 1 October 2010
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| Systematic name | YPR068C |
| Gene name | HOS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:684350..682938 |
| Primary SGDID | S000006272 |
Description of YPR068C: Class I histone deacetylase (HDAC) family member that also deacetylates Smc3p at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex[1][2][3][4]
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Community Commentary
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Protein Details
Protein Function/Process
In Robyr et al (2002), antibodies to specific acetyl forms of histones were used to find regions of the genome that increased in acetylation when certain histone deacetylases were deleted. Deletion of Hos1 resulted in increased acetylation primarily at the rDNA repeats. [3] [5]
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References
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- ↑ Borges V, et al. (2010) Hos1 deacetylates smc3 to close the cohesin acetylation cycle. Mol Cell 39(5):677-88 SGD PMID 20832720
- ↑ Davie JK, et al. (2003) Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62 SGD PMID 14525981
- ↑ 3.0 3.1 Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 SGD PMID 12086601
- ↑ Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 SGD PMID 8962081
- ↑ submitted by Hunter Fraser on 2003-04-18
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