Difference between revisions of "YPR068C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YPR068C YPR068C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006272 YPR068C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HOS1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HOS1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XVI:684350..682938
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|nowrap| Chr XVI:684353..682941
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000006272
 
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'''Description of {{PAGENAME}}:''' Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex<ref name='S000075178'>Davie JK, et al. (2003) Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62 {{SGDpaper|S000075178}} PMID 14525981</ref><ref name='S000070188'>Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 {{SGDpaper|S000070188}} PMID 12086601</ref><ref name='S000047708'>Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8
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'''Description of YPR068C:''' Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex<ref name='S000136515'>Borges V, et al. (2010) Hos1 deacetylates smc3 to close the cohesin acetylation cycle. Mol Cell 39(5):677-88 {{SGDpaper|S000136515}} PMID 20832720</ref><ref name='S000075178'>Davie JK, et al. (2003) Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62 {{SGDpaper|S000075178}} PMID 14525981</ref><ref name='S000070188'>Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 {{SGDpaper|S000070188}} PMID 12086601</ref><ref name='S000047708'>Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 {{SGDpaper|S000047708}} PMID 8962081</ref><ref name='S000135969'>Xiong B, et al. (2010) Hos1 is a lysine deacetylase for the smc3 subunit of cohesin. Curr Biol 20(18):1660-5
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  {{SGDpaper|S000135969}} PMID 20797861</ref>
 
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==Community Commentary==
 
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=== Protein Details ===
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==== Protein Function/Process ====
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In Robyr et al (2002), antibodies to specific acetyl forms of histones were used to find regions of the genome that increased in acetylation when certain histone deacetylases were deleted. Deletion of Hos1 resulted in increased acetylation primarily at the rDNA repeats. <ref name='S000070188'>Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 {{SGDpaper|S000070188}} PMID 12086601</ref> <ref name = 'CAset9199-2003-04-18'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9199 Hunter Fraser] on 2003-04-18</ref>
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YPR068C
Gene name HOS1
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:684353..682941
Primary SGDID S000006272


Description of YPR068C: Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex[1][2][3][4][5]




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Community Commentary

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Protein Details

Protein Function/Process

In Robyr et al (2002), antibodies to specific acetyl forms of histones were used to find regions of the genome that increased in acetylation when certain histone deacetylases were deleted. Deletion of Hos1 resulted in increased acetylation primarily at the rDNA repeats. [3] [6]




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References

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  1. ↑ Borges V, et al. (2010) Hos1 deacetylates smc3 to close the cohesin acetylation cycle. Mol Cell 39(5):677-88 SGD PMID 20832720
  2. ↑ Davie JK, et al. (2003) Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62 SGD PMID 14525981
  3. ↑ 3.0 3.1 Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 SGD PMID 12086601
  4. ↑ Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 SGD PMID 8962081
  5. ↑ Xiong B, et al. (2010) Hos1 is a lysine deacetylase for the smc3 subunit of cohesin. Curr Biol 20(18):1660-5 SGD PMID 20797861
  6. ↑ submitted by Hunter Fraser on 2003-04-18

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