Difference between revisions of "YLR256W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004246 YLR256W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HAP1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HAP1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XII: | + | |nowrap| Chr XII:646415..650923 |
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004246 |
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| − | '''Description of | + | '''Description of YLR256W:''' Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus<ref name='S000051360'>Gaisne M, et al. (1999) A 'natural' mutation in Saccharomyces cerevisiae strains derived from S288c affects the complex regulatory gene HAP1 (CYP1). Curr Genet 36(4):195-200 {{SGDpaper|S000051360}} PMID 10541856</ref><ref name='S000041863'>Keng T (1992) HAP1 and ROX1 form a regulatory pathway in the repression of HEM13 transcription in Saccharomyces cerevisiae. Mol Cell Biol 12(6):2616-23 {{SGDpaper|S000041863}} PMID 1588959</ref><ref name='S000061155'>Kwast KE, et al. (1998) Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast. J Exp Biol 201(Pt 8):1177-95 {{SGDpaper|S000061155}} PMID 9510529</ref><ref name='S000050602'>Pfeifer K, et al. (1987) Yeast HAP1 activator binds to two upstream activation sites of different sequence. Cell 49(1):19-27 {{SGDpaper|S000050602}} PMID 3030565</ref><ref name='S000048461'>Pfeifer K, et al. (1989) Functional dissection and sequence of yeast HAP1 activator. Cell 56(2):291-301 |
| − | + | {{SGDpaper|S000048461}} PMID 2643482</ref> | |
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==Community Commentary== | ==Community Commentary== | ||
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| + | === Interactions === | ||
| + | [[Category:Topic:Interactions]] | ||
| + | ==== Regulatory ==== | ||
| + | [[Category:Topic:Interactions:Regulatory]] | ||
| + | Regulatory interaction with YBL064c [[Category:Regulatory Interactions with YBL064c]]<br> | ||
| + | YBL064c mRNA expression was induced by peroxides in a time- and dose-dependent manner and varied with the carbon source present in the media. Deletion of HAP1 or inhibition of heme synthesis abolished induction of YBL064c mRNA expression by H2O2 on cells which were grown in media containing glucose, indicating that Hap1p is involved in the regulation of this process. <ref name='S000069137'>Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 {{SGDpaper|S000069137}} PMID 11827753</ref> <ref name = 'CAset9246-2003-03-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9246 Gisele Monteiro] on 2003-03-31</ref> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 06:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YLR256W |
| Gene name | HAP1 |
| Aliases | CYP1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:646415..650923 |
| Primary SGDID | S000004246 |
Description of YLR256W: Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus[1][2][3][4][5]
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Community Commentary
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Interactions
Regulatory
Regulatory interaction with YBL064c
YBL064c mRNA expression was induced by peroxides in a time- and dose-dependent manner and varied with the carbon source present in the media. Deletion of HAP1 or inhibition of heme synthesis abolished induction of YBL064c mRNA expression by H2O2 on cells which were grown in media containing glucose, indicating that Hap1p is involved in the regulation of this process. [6] [7]
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References
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- ↑ Gaisne M, et al. (1999) A 'natural' mutation in Saccharomyces cerevisiae strains derived from S288c affects the complex regulatory gene HAP1 (CYP1). Curr Genet 36(4):195-200 SGD PMID 10541856
- ↑ Keng T (1992) HAP1 and ROX1 form a regulatory pathway in the repression of HEM13 transcription in Saccharomyces cerevisiae. Mol Cell Biol 12(6):2616-23 SGD PMID 1588959
- ↑ Kwast KE, et al. (1998) Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast. J Exp Biol 201(Pt 8):1177-95 SGD PMID 9510529
- ↑ Pfeifer K, et al. (1987) Yeast HAP1 activator binds to two upstream activation sites of different sequence. Cell 49(1):19-27 SGD PMID 3030565
- ↑ Pfeifer K, et al. (1989) Functional dissection and sequence of yeast HAP1 activator. Cell 56(2):291-301 SGD PMID 2643482
- ↑ Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 SGD PMID 11827753
- ↑ submitted by Gisele Monteiro on 2003-03-31
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