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Systematic name YLR256W
Gene name HAP1
Aliases CYP1
Feature type ORF, Verified
Coordinates Chr XII:646415..650923
Primary SGDID S000004246

Description of YLR256W: Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus[1][2][3][4][5]


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Regulatory interaction with YBL064c
YBL064c mRNA expression was induced by peroxides in a time- and dose-dependent manner and varied with the carbon source present in the media. Deletion of HAP1 or inhibition of heme synthesis abolished induction of YBL064c mRNA expression by H2O2 on cells which were grown in media containing glucose, indicating that Hap1p is involved in the regulation of this process. [6] [7]



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  1. Gaisne M, et al. (1999) A 'natural' mutation in Saccharomyces cerevisiae strains derived from S288c affects the complex regulatory gene HAP1 (CYP1). Curr Genet 36(4):195-200 SGD PMID 10541856
  2. Keng T (1992) HAP1 and ROX1 form a regulatory pathway in the repression of HEM13 transcription in Saccharomyces cerevisiae. Mol Cell Biol 12(6):2616-23 SGD PMID 1588959
  3. Kwast KE, et al. (1998) Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast. J Exp Biol 201(Pt 8):1177-95 SGD PMID 9510529
  4. Pfeifer K, et al. (1987) Yeast HAP1 activator binds to two upstream activation sites of different sequence. Cell 49(1):19-27 SGD PMID 3030565
  5. Pfeifer K, et al. (1989) Functional dissection and sequence of yeast HAP1 activator. Cell 56(2):291-301 SGD PMID 2643482
  6. Monteiro G, et al. (2002) Regulation of mitochondrial thioredoxin peroxidase I expression by two different pathways: one dependent on cAMP and the other on heme. Free Radic Biol Med 32(3):278-88 SGD PMID 11827753
  7. submitted by Gisele Monteiro on 2003-03-31

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