Difference between revisions of "YNL323W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005267 YNL323W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''LEM3 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''LEM3 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XIV: | + | |nowrap| Chr XIV:31944..33188 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005267 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000005267 | ||
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| − | '''Description of YNL323W:''' Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane<ref name='S000074019'>Hanson PK, et al. (2003) Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. J Biol Chem 278(38):36041-50 {{SGDpaper|S000074019}} PMID 12842877</ref><ref name='S000071454'>Kato U, et al. (2002) A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae. J Biol Chem 277(40):37855-62 | + | '''Description of YNL323W:''' Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane<ref name='S000074019'>Hanson PK, et al. (2003) Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. J Biol Chem 278(38):36041-50 {{SGDpaper|S000074019}} PMID 12842877</ref><ref name='S000071454'>Kato U, et al. (2002) A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae. J Biol Chem 277(40):37855-62 {{SGDpaper|S000071454}} PMID 12133835</ref><ref name='S000130257'>Lenoir G, et al. (2009) Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter drs2p. J Biol Chem 284(27):17956-67 |
| − | {{SGDpaper| | + | {{SGDpaper|S000130257}} PMID 19411703</ref> |
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Latest revision as of 06:45, 23 January 2012
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| Systematic name | YNL323W |
| Gene name | LEM3 |
| Aliases | BRE3, ROS3 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:31944..33188 |
| Primary SGDID | S000005267 |
Description of YNL323W: Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane[1][2][3]
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References
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- ↑ Hanson PK, et al. (2003) Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. J Biol Chem 278(38):36041-50 SGD PMID 12842877
- ↑ Kato U, et al. (2002) A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae. J Biol Chem 277(40):37855-62 SGD PMID 12133835
- ↑ Lenoir G, et al. (2009) Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter drs2p. J Biol Chem 284(27):17956-67 SGD PMID 19411703
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