YNL323W
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| Systematic name | YNL323W |
| Gene name | LEM3 |
| Aliases | BRE3, ROS3 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:31944..33188 |
| Primary SGDID | S000005267 |
Description of YNL323W: Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane[1][2][3]
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References
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- ↑ Hanson PK, et al. (2003) Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. J Biol Chem 278(38):36041-50 SGD PMID 12842877
- ↑ Kato U, et al. (2002) A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae. J Biol Chem 277(40):37855-62 SGD PMID 12133835
- ↑ Lenoir G, et al. (2009) Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter drs2p. J Biol Chem 284(27):17956-67 SGD PMID 19411703
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