Difference between revisions of "YDR477W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YDR477W YDR477W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002885 YDR477W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SNF1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SNF1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr IV:1412365..1414266
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|nowrap| Chr IV:1412373..1414274
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002885
 
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'''Description of {{PAGENAME}}:''' AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis<ref name='S000081044'>Hardie DG, et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67():821-55 {{SGDpaper|S000081044}} PMID 9759505</ref><ref name='S000074313'>Sanz P (2003) Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem Soc Trans 31(Pt 1):178-81
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'''Description of YDR477W:''' AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis<ref name='S000081044'>Hardie DG, et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67():821-55 {{SGDpaper|S000081044}} PMID 9759505</ref><ref name='S000074313'>Sanz P (2003) Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem Soc Trans 31(Pt 1):178-81
 
  {{SGDpaper|S000074313}} PMID 12546680</ref>
 
  {{SGDpaper|S000074313}} PMID 12546680</ref>
 
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__TOC__
 
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==Community Commentary==
 
==Community Commentary==
 
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=== Alleles, Strains, and Phenotypes ===
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[[Category:Topic:Alleles, Strains, and Phenotypes]]
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==== Multiple Knockout Strains ====
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[[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]]
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'''Strain Background''': Sigma1278b<br>
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'''Genotype''': MCY4461<br>
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'''Together with''': REG1<br>
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'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
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Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
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{{ShortCenteredHR}}
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=== Interactions ===
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[[Category:Topic:Interactions]]
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==== Genetic ====
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[[Category:Topic:Interactions:Genetic]]
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YDR477W is suppressed by  Nrg2 [[Category:Genetic Interaction with Nrg2]]
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 +
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'''Strain Background''': Sigma 1278b<br>
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'''Mutation type(s)''': complete deletion, complete deletion
 +
 +
Deletion of Nrg2 partially suppresses Snf1's defect in invasive growth, biofilm formation, FLO11 expression, and STA2 expression. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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 +
{{ShortCenteredHR}}
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YDR477W is suppressed by  Nrg1 [[Category:Genetic Interaction with Nrg1]]
 +
 +
 +
'''Strain Background''': Sigma 1278b<br>
 +
'''Mutation type(s)''': complete deletion, complete deletion
 +
 +
Deletion of Nrg1 partially suppresses Snf1's defect in invasive growth, FLO11 expression, and STA2 expression. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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{{ShortCenteredHR}}
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==== Physical ====
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[[Category:Topic:Interactions:Physical]]
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Physical interaction with Nrg2 [[Category:Physical Interactions with Nrg2]]<br>
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Snf1 coimmunoprecipitates with HA3-Nrg2 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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{{ShortCenteredHR}}
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Physical interaction with Nrg2 [[Category:Physical Interactions with Nrg2]]<br>
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LexA-Snf1 coimmunoprecipitates HA3-Nrg2 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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{{ShortCenteredHR}}
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Physical interaction with Nrg1 [[Category:Physical Interactions with Nrg1]]<br>
 +
Snf1 coimmunoprecipitates with HA3-Nrg1 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
 +
 +
{{ShortCenteredHR}}
 +
Physical interaction with Nrg1 [[Category:Physical Interactions with Nrg1]]<br>
 +
LexA-Snf1 coimmunoprecipitates HA3-Nrg1 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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{{ShortCenteredHR}}
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==== Two Hybrid ====
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[[Category:Topic:Interactions:Two Hybrid]]
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Two Hybrid interaction with Nrg2 [[Category:Two Hybrid Interactions with Nrg2]]<br>
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Snf1 kinase domain interacts with Nrg2 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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{{ShortCenteredHR}}
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Two Hybrid interaction with nrg1 [[Category:Two Hybrid Interactions with nrg1]]<br>
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Snf1 kinase domain interacts with Nrg1 <ref name='S000060795'>Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 {{SGDpaper|S000060795}} PMID 11404322</ref> <ref name = 'CAset6176-2003-02-04'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-02-04</ref>
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{{ShortCenteredHR}}
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 06:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YDR477W
Gene name SNF1
Aliases CAT1, CCR1, GLC2, HAF3, PAS14
Feature type ORF, Verified
Coordinates Chr IV:1412373..1414274
Primary SGDID S000002885


Description of YDR477W: AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis[1][2]




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Community Commentary

About Community Commentary. Please share your knowledge!

Alleles, Strains, and Phenotypes

Multiple Knockout Strains

Strain Background: Sigma1278b
Genotype: MCY4461
Together with: REG1
Phenotype(s): Loss of function (Null)

Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. [3] [4]

Interactions

Genetic

YDR477W is suppressed by Nrg2


Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion

Deletion of Nrg2 partially suppresses Snf1's defect in invasive growth, biofilm formation, FLO11 expression, and STA2 expression. [3] [5]

YDR477W is suppressed by Nrg1


Strain Background: Sigma 1278b
Mutation type(s): complete deletion, complete deletion

Deletion of Nrg1 partially suppresses Snf1's defect in invasive growth, FLO11 expression, and STA2 expression. [3] [5]

Physical

Physical interaction with Nrg2
Snf1 coimmunoprecipitates with HA3-Nrg2 [6] [5]

Physical interaction with Nrg2
LexA-Snf1 coimmunoprecipitates HA3-Nrg2 [6] [5]

Physical interaction with Nrg1
Snf1 coimmunoprecipitates with HA3-Nrg1 [6] [5]

Physical interaction with Nrg1
LexA-Snf1 coimmunoprecipitates HA3-Nrg1 [6] [5]

Two Hybrid

Two Hybrid interaction with Nrg2
Snf1 kinase domain interacts with Nrg2 [6] [5]

Two Hybrid interaction with nrg1
Snf1 kinase domain interacts with Nrg1 [6] [5]




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References

See Help:References on how to add references

  1. ↑ Hardie DG, et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67():821-55 SGD PMID 9759505
  2. ↑ Sanz P (2003) Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem Soc Trans 31(Pt 1):178-81 SGD PMID 12546680
  3. ↑ 3.0 3.1 3.2 Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 SGD PMID 12024013
  4. ↑ submitted by Valmik K. Vyas on 2003-03-27
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 submitted by Valmik K. Vyas on 2003-02-04
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Vyas VK, et al. (2001) Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Genetics 158(2):563-72 SGD PMID 11404322

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