Difference between revisions of "YGL066W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YGL066W YGL066W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003034 YGL066W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SGF73 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SGF73 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''sca7''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''SCA7''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr VII:377612..379585
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|nowrap| Chr VII:377609..379582
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003034
 
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'''Description of {{PAGENAME}}:''' 73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters<ref name='S000119604'>Shukla A, et al. (2006) SAGA-associated Sgf73p facilitates formation of the preinitiation complex assembly at the promoters either in a HAT-dependent or independent manner in vivo. Nucleic Acids Res 34(21):6225-32 {{SGDpaper|S000119604}} PMID 17090597</ref><ref name='S000070225'>Sanders SL, et al. (2002) Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol Cell Biol 22(13):4723-38
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'''Description of YGL066W:''' SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay<ref name='S000121894'>Helmlinger D, et al. (2004) Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes. Hum Mol Genet 13(12):1257-65 {{SGDpaper|S000121894}} PMID 15115762</ref><ref name='S000124986'>Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222 {{SGDpaper|S000124986}} PMID 18069899</ref><ref name='S000129354'>Lee KK, et al. (2009) Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes. Epigenetics Chromatin 2(1):2 {{SGDpaper|S000129354}} PMID 19226466</ref><ref name='S000081847'>McMahon SJ, et al. (2005) Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity. Proc Natl Acad Sci U S A 102(24):8478-82 {{SGDpaper|S000081847}} PMID 15932941</ref><ref name='S000070225'>Sanders SL, et al. (2002) Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol Cell Biol 22(13):4723-38 {{SGDpaper|S000070225}} PMID 12052880</ref><ref name='S000119604'>Shukla A, et al. (2006) SAGA-associated Sgf73p facilitates formation of the preinitiation complex assembly at the promoters either in a HAT-dependent or independent manner in vivo. Nucleic Acids Res 34(21):6225-32 {{SGDpaper|S000119604}} PMID 17090597</ref><ref name='S000146226'>Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64
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  {{SGDpaper|S000070225}} PMID 12052880</ref>
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  {{SGDpaper|S000146226}} PMID 21478823</ref>
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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J Biol Chem 278(5):3265-74</ref>
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YGL066W
Gene name SGF73
Aliases SCA7
Feature type ORF, Verified
Coordinates Chr VII:377609..379582
Primary SGDID S000003034


Description of YGL066W: SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay[1][2][3][4][5][6][7]




</protect>

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References

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  1. ↑ Helmlinger D, et al. (2004) Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes. Hum Mol Genet 13(12):1257-65 SGD PMID 15115762
  2. ↑ Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222 SGD PMID 18069899
  3. ↑ Lee KK, et al. (2009) Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes. Epigenetics Chromatin 2(1):2 SGD PMID 19226466
  4. ↑ McMahon SJ, et al. (2005) Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity. Proc Natl Acad Sci U S A 102(24):8478-82 SGD PMID 15932941
  5. ↑ Sanders SL, et al. (2002) Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol Cell Biol 22(13):4723-38 SGD PMID 12052880
  6. ↑ Shukla A, et al. (2006) SAGA-associated Sgf73p facilitates formation of the preinitiation complex assembly at the promoters either in a HAT-dependent or independent manner in vivo. Nucleic Acids Res 34(21):6225-32 SGD PMID 17090597
  7. ↑ Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64 SGD PMID 21478823

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