Difference between revisions of "YFL007W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YFL007W YFL007W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001887 YFL007W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''BLM10 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''BLM10 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr VI:123474..129905
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|nowrap| Chr VI:123479..129910
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001887
 
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'''Description of {{PAGENAME}}:''' Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200<ref name='S000114402'>Ustrell V, et al. (2002) PA200, a nuclear proteasome activator involved in DNA repair. EMBO J 21(13):3516-25 {{SGDpaper|S000114402}} PMID 12093752</ref><ref name='S000081108'>Schmidt M, et al. (2005) The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol 12(4):294-303 {{SGDpaper|S000081108}} PMID 15778719</ref><ref name='S000077319'>Doherty K, et al. (2004) Expression of the expanded YFL007w ORF and assignment of the gene name BLM10. Yeast 21(12):1021-3 {{SGDpaper|S000077319}} PMID 15449308</ref><ref name='S000076318'>Fehlker M, et al. (2003) Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assembly. EMBO Rep 4(10):959-63 {{SGDpaper|S000076318}} PMID 12973301</ref><ref name='S000069159'>Febres DE, et al. (2001) The novel BLM3 gene encodes a protein that protects against lethal effects of oxidative damage. Cell Mol Biol (Noisy-le-grand) 47(7):1149-62
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'''Description of YFL007W:''' Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200<ref name='S000147225'>Dange T, et al. (2011) Blm10 promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem () {{SGDpaper|S000147225}} PMID 22025621</ref><ref name='S000077319'>Doherty K, et al. (2004) Expression of the expanded YFL007w ORF and assignment of the gene name BLM10. Yeast 21(12):1021-3 {{SGDpaper|S000077319}} PMID 15449308</ref><ref name='S000069159'>Febres DE, et al. (2001) The novel BLM3 gene encodes a protein that protects against lethal effects of oxidative damage. Cell Mol Biol (Noisy-le-grand) 47(7):1149-62 {{SGDpaper|S000069159}} PMID 11842813</ref><ref name='S000076318'>Fehlker M, et al. (2003) Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assembly. EMBO Rep 4(10):959-63 {{SGDpaper|S000076318}} PMID 12973301</ref><ref name='S000081108'>Schmidt M, et al. (2005) The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol 12(4):294-303 {{SGDpaper|S000081108}} PMID 15778719</ref><ref name='S000114402'>Ustrell V, et al. (2002) PA200, a nuclear proteasome activator involved in DNA repair. EMBO J 21(13):3516-25
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  {{SGDpaper|S000114402}} PMID 12093752</ref>
 
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J Biol Chem 278(5):3265-74</ref>
 
J Biol Chem 278(5):3265-74</ref>
 
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Latest revision as of 13:05, 10 February 2012

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Systematic name YFL007W
Gene name BLM10
Aliases YFL006W
Feature type ORF, Verified
Coordinates Chr VI:123479..129910
Primary SGDID S000001887


Description of YFL007W: Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200[1][2][3][4][5][6]




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References

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  1. ↑ Dange T, et al. (2011) Blm10 promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem () SGD PMID 22025621
  2. ↑ Doherty K, et al. (2004) Expression of the expanded YFL007w ORF and assignment of the gene name BLM10. Yeast 21(12):1021-3 SGD PMID 15449308
  3. ↑ Febres DE, et al. (2001) The novel BLM3 gene encodes a protein that protects against lethal effects of oxidative damage. Cell Mol Biol (Noisy-le-grand) 47(7):1149-62 SGD PMID 11842813
  4. ↑ Fehlker M, et al. (2003) Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assembly. EMBO Rep 4(10):959-63 SGD PMID 12973301
  5. ↑ Schmidt M, et al. (2005) The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol 12(4):294-303 SGD PMID 15778719
  6. ↑ Ustrell V, et al. (2002) PA200, a nuclear proteasome activator involved in DNA repair. EMBO J 21(13):3516-25 SGD PMID 12093752

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