YFL007W
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| Systematic name | YFL007W |
| Gene name | BLM10 |
| Aliases | YFL006W |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:123479..129910 |
| Primary SGDID | S000001887 |
Description of YFL007W: Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200[1][2][3][4][5][6]
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References
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- ↑ Dange T, et al. (2011) Blm10 promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem () SGD PMID 22025621
- ↑ Doherty K, et al. (2004) Expression of the expanded YFL007w ORF and assignment of the gene name BLM10. Yeast 21(12):1021-3 SGD PMID 15449308
- ↑ Febres DE, et al. (2001) The novel BLM3 gene encodes a protein that protects against lethal effects of oxidative damage. Cell Mol Biol (Noisy-le-grand) 47(7):1149-62 SGD PMID 11842813
- ↑ Fehlker M, et al. (2003) Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assembly. EMBO Rep 4(10):959-63 SGD PMID 12973301
- ↑ Schmidt M, et al. (2005) The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol 12(4):294-303 SGD PMID 15778719
- ↑ Ustrell V, et al. (2002) PA200, a nuclear proteasome activator involved in DNA repair. EMBO J 21(13):3516-25 SGD PMID 12093752
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