Difference between revisions of "YDR026C"
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| − | '''Description of YDR026C:''' | + | '''Description of YDR026C:''' RNA polymerase I termination factor; binds to the rDNA terminator element and is required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities the association of Sir2p with NTS1, and contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein with similarity to Reb1p<ref name='S000115662'>Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 {{SGDpaper|S000115662}} PMID 16702403</ref><ref name='S000148603'>Ha CW, et al. (2012) Nsi1 plays a significant role in the silencing of ribosomal DNA in Saccharomyces cerevisiae. Nucleic Acids Res () {{SGDpaper|S000148603}} PMID 22362748</ref><ref name='S000075342'>Mohanty BK and Bastia D (2004) Binding of the replication terminator protein Fob1p to the Ter sites of yeast causes polar fork arrest. J Biol Chem 279(3):1932-41 {{SGDpaper|S000075342}} PMID 14576157</ref><ref name='S000150213'>Reiter A, et al. (2012) The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast.LID - 10.1038/emboj.2012.185 [doi] EMBO J () |
| − | {{SGDpaper| | + | {{SGDpaper|S000150213}} PMID 22805593</ref> |
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Latest revision as of 13:05, 1 August 2012
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| Systematic name | YDR026C |
| Gene name | NSI1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:494268..492556 |
| Primary SGDID | S000002433 |
Description of YDR026C: RNA polymerase I termination factor; binds to the rDNA terminator element and is required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities the association of Sir2p with NTS1, and contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein with similarity to Reb1p[1][2][3][4]
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References
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- ↑ Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 SGD PMID 16702403
- ↑ Ha CW, et al. (2012) Nsi1 plays a significant role in the silencing of ribosomal DNA in Saccharomyces cerevisiae. Nucleic Acids Res () SGD PMID 22362748
- ↑ Mohanty BK and Bastia D (2004) Binding of the replication terminator protein Fob1p to the Ter sites of yeast causes polar fork arrest. J Biol Chem 279(3):1932-41 SGD PMID 14576157
- ↑ Reiter A, et al. (2012) The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast.LID - 10.1038/emboj.2012.185 [doi] EMBO J () SGD PMID 22805593
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