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Systematic name YDR026C
Gene name NSI1
Feature type ORF, Verified
Coordinates Chr IV:494268..492556
Primary SGDID S000002433

Description of YDR026C: RNA polymerase I termination factor; binds to the rDNA terminator element and is required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities the association of Sir2p with NTS1, and contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein with similarity to Reb1p[1][2][3][4]


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  1. Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 SGD PMID 16702403
  2. Ha CW, et al. (2012) Nsi1 plays a significant role in the silencing of ribosomal DNA in Saccharomyces cerevisiae. Nucleic Acids Res () SGD PMID 22362748
  3. Mohanty BK and Bastia D (2004) Binding of the replication terminator protein Fob1p to the Ter sites of yeast causes polar fork arrest. J Biol Chem 279(3):1932-41 SGD PMID 14576157
  4. Reiter A, et al. (2012) The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast.LID - 10.1038/emboj.2012.185 [doi] EMBO J () SGD PMID 22805593

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