Difference between revisions of "YHR030C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001072 YHR030C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SLT2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SLT2 '' | ||
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| − | '''Description of YHR030C:''' Serine/threonine MAP kinase involved in regulating | + | '''Description of YHR030C:''' Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway<ref name='S000136274'>Carmody SR, et al. (2010) The Mitogen-Activated Protein Kinase Slt2 Regulates Nuclear Retention of Non-Heat Shock mRNAs during Heat Shock-Induced Stress. Mol Cell Biol 30(21):5168-79 {{SGDpaper|S000136274}} PMID 20823268</ref><ref name='S000133411'>Kim KY, et al. (2010) Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Mol Biol Cell 21(9):1609-19 {{SGDpaper|S000133411}} PMID 20219973</ref><ref name='S000058057'>Madden K, et al. (1997) SBF cell cycle regulator as a target of the yeast PKC-MAP kinase pathway. Science 275(5307):1781-4 {{SGDpaper|S000058057}} PMID 9065400</ref><ref name='S000145416'>Mao K, et al. (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67 {{SGDpaper|S000145416}} PMID 21576396</ref><ref name='S000073735'>Martin-Yken H, et al. (2003) The interaction of Slt2 MAP kinase with Knr4 is necessary for signalling through the cell wall integrity pathway in Saccharomyces cerevisiae. Mol Microbiol 49(1):23-35 {{SGDpaper|S000073735}} PMID 12823808</ref><ref name='S000043729'>Watanabe Y, et al. (1995) Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol 15(10):5740-9 |
{{SGDpaper|S000043729}} PMID 7565726</ref> | {{SGDpaper|S000043729}} PMID 7565726</ref> | ||
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Latest revision as of 06:45, 23 January 2012
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| Systematic name | YHR030C |
| Gene name | SLT2 |
| Aliases | BYC2, MPK1, SLK2 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:170344..168890 |
| Primary SGDID | S000001072 |
Description of YHR030C: Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway[1][2][3][4][5][6]
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References
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- ↑ Carmody SR, et al. (2010) The Mitogen-Activated Protein Kinase Slt2 Regulates Nuclear Retention of Non-Heat Shock mRNAs during Heat Shock-Induced Stress. Mol Cell Biol 30(21):5168-79 SGD PMID 20823268
- ↑ Kim KY, et al. (2010) Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Mol Biol Cell 21(9):1609-19 SGD PMID 20219973
- ↑ Madden K, et al. (1997) SBF cell cycle regulator as a target of the yeast PKC-MAP kinase pathway. Science 275(5307):1781-4 SGD PMID 9065400
- ↑ Mao K, et al. (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67 SGD PMID 21576396
- ↑ Martin-Yken H, et al. (2003) The interaction of Slt2 MAP kinase with Knr4 is necessary for signalling through the cell wall integrity pathway in Saccharomyces cerevisiae. Mol Microbiol 49(1):23-35 SGD PMID 12823808
- ↑ Watanabe Y, et al. (1995) Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol 15(10):5740-9 SGD PMID 7565726
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