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Systematic name YHR030C
Gene name SLT2
Aliases BYC2, MPK1, SLK2
Feature type ORF, Verified
Coordinates Chr VIII:170344..168890
Primary SGDID S000001072

Description of YHR030C: Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway[1][2][3][4][5][6]


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  1. Carmody SR, et al. (2010) The Mitogen-Activated Protein Kinase Slt2 Regulates Nuclear Retention of Non-Heat Shock mRNAs during Heat Shock-Induced Stress. Mol Cell Biol 30(21):5168-79 SGD PMID 20823268
  2. Kim KY, et al. (2010) Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Mol Biol Cell 21(9):1609-19 SGD PMID 20219973
  3. Madden K, et al. (1997) SBF cell cycle regulator as a target of the yeast PKC-MAP kinase pathway. Science 275(5307):1781-4 SGD PMID 9065400
  4. Mao K, et al. (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67 SGD PMID 21576396
  5. Martin-Yken H, et al. (2003) The interaction of Slt2 MAP kinase with Knr4 is necessary for signalling through the cell wall integrity pathway in Saccharomyces cerevisiae. Mol Microbiol 49(1):23-35 SGD PMID 12823808
  6. Watanabe Y, et al. (1995) Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol 15(10):5740-9 SGD PMID 7565726

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