Difference between revisions of "YBL032W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YBL032W YBL032W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000128 YBL032W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HEK2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HEK2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr II:160187..161332
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|nowrap| Chr II:160184..161329
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000128
 
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'''Description of {{PAGENAME}}:''' RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length<ref name='S000069530'>Irie K, et al. (2002) The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J 21(5):1158-67 {{SGDpaper|S000069530}} PMID 11867544</ref><ref name='S000069066'>Denisenko O and Bomsztyk K (2002) Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length. Mol Cell Biol 22(1):286-97
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'''Description of YBL032W:''' RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K<ref name='S000069066'>Denisenko O and Bomsztyk K (2002) Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length. Mol Cell Biol 22(1):286-97 {{SGDpaper|S000069066}} PMID 11739741</ref><ref name='S000069530'>Irie K, et al. (2002) The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J 21(5):1158-67 {{SGDpaper|S000069530}} PMID 11867544</ref><ref name='S000123126'>Paquin N, et al. (2007) Local Activation of Yeast ASH1 mRNA Translation through Phosphorylation of Khd1p by the Casein Kinase Yck1p. Mol Cell 26(6):795-809
  {{SGDpaper|S000069066}} PMID 11739741</ref>
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  {{SGDpaper|S000123126}} PMID 17588515</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Latest revision as of 06:45, 23 January 2012

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Systematic name YBL032W
Gene name HEK2
Aliases KHD1
Feature type ORF, Verified
Coordinates Chr II:160184..161329
Primary SGDID S000000128


Description of YBL032W: RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K[1][2][3]




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References

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  1. Denisenko O and Bomsztyk K (2002) Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length. Mol Cell Biol 22(1):286-97 SGD PMID 11739741
  2. Irie K, et al. (2002) The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J 21(5):1158-67 SGD PMID 11867544
  3. Paquin N, et al. (2007) Local Activation of Yeast ASH1 mRNA Translation through Phosphorylation of Khd1p by the Casein Kinase Yck1p. Mol Cell 26(6):795-809 SGD PMID 17588515

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