Difference between revisions of "YGR140W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003372 YGR140W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003372 YGR140W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''CBF2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''CBF2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr VII:767434..770304
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|nowrap| Chr VII:767429..770299
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003372
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003372
 
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'''Description of YGR140W:''' Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo<ref name='S000044125'>Lechner J and Carbon J (1991) A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell 64(4):717-25 {{SGDpaper|S000044125}} PMID 1997204</ref><ref name='S000054823'>Yoon HJ and Carbon J (1995) Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme. Mol Cell Biol 15(9):4835-42 {{SGDpaper|S000054823}} PMID 7651401</ref><ref name='S000074756'>Espelin CW, et al. (2003) Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell 14(11):4557-68
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'''Description of YGR140W:''' Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo<ref name='S000074756'>Espelin CW, et al. (2003) Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell 14(11):4557-68 {{SGDpaper|S000074756}} PMID 13679521</ref><ref name='S000044125'>Lechner J and Carbon J (1991) A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell 64(4):717-25 {{SGDpaper|S000044125}} PMID 1997204</ref><ref name='S000054823'>Yoon HJ and Carbon J (1995) Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme. Mol Cell Biol 15(9):4835-42
{{SGDpaper|S000074756}} PMID 13679521</ref>
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{{SGDpaper|S000054823}} PMID 7651401</ref>
 
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Latest revision as of 06:45, 23 January 2012

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Systematic name YGR140W
Gene name CBF2
Aliases CBF3A, CEP2, CSL5, CTF14, NDC10
Feature type ORF, Verified
Coordinates Chr VII:767429..770299
Primary SGDID S000003372


Description of YGR140W: Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo[1][2][3]




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Community Commentary

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Interactions

Genetic

Strain Background: A364A/S288C
Genetic interaction with MIF2
Phenotype(s): Synthetic Lethal with MIF2

at the time showed that MIF2 genetically interacts with an "established" centromere protein gene [4] [5]





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References

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  1. Espelin CW, et al. (2003) Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell 14(11):4557-68 SGD PMID 13679521
  2. Lechner J and Carbon J (1991) A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell 64(4):717-25 SGD PMID 1997204
  3. Yoon HJ and Carbon J (1995) Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme. Mol Cell Biol 15(9):4835-42 SGD PMID 7651401
  4. Meluh PB and Koshland D (1995) Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol Biol Cell 6(7):793-807 SGD PMID 7579695
  5. submitted by Pamela B. Meluh on 2003-03-17

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