Difference between revisions of "YBR135W"

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'''Description of YBR135W:''' Subunit of the Cdc28 protein kinase, required for mitotic proteolysis, may also be involved in the proteolysis of the G1 cyclins<ref name='S000074880'>Ceccarelli E and Mann C (2001) A Cdc28 mutant uncouples G1 cyclin phosphorylation and ubiquitination from G1 cyclin proteolysis. J Biol Chem 276(45):41725-32
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'''Description of YBR135W:''' Cyclin-dependent protein kinase subunit; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation through the recruitment of proteasomal subunits to target gene promoters<ref name='S000073499'>Morris MC, et al. (2003) Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast. Nature 423(6943):1009-13 {{SGDpaper|S000073499}} PMID 12827207</ref><ref name='S000054457'>Kaiser P, et al. (1999) Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes Dev 13(9):1190-202
  {{SGDpaper|S000074880}} PMID 11527976</ref>
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  {{SGDpaper|S000054457}} PMID 10323869</ref>
 
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Revision as of 13:05, 9 August 2007

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Systematic name YBR135W
Gene name CKS1
Aliases
Feature type ORF, Verified
Coordinates Chr II:504848..505300
Primary SGDID S000000339


Description of YBR135W: Cyclin-dependent protein kinase subunit; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation through the recruitment of proteasomal subunits to target gene promoters[1][2]




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References

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  1. Morris MC, et al. (2003) Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast. Nature 423(6943):1009-13 SGD PMID 12827207
  2. Kaiser P, et al. (1999) Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes Dev 13(9):1190-202 SGD PMID 10323869

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